Sagal began her career working the Hollywood circuit. She appeared within many television movies between 1971 and 1975, including the Columbo picture Candidate for Crime and around 1973 working as a back-up singer for various mega-stars including Bob Dylan, Gene Simmons, and Tanya Tucker. She was plucked from either proportional obscurity by Bette Midler, who hired her for her 1979 tour as one of her back-up singers (The Harlettes).

Sagal returned to television inside 1985 in the failed television series Mary starring Mary Tyler Moore. This led to her existence cast inside her virtually all easily-known role, that of Peg Bundy on the super successful Our contries sitcom Married... with Children. On the indicate, she portrayed the lower-class, unhappy, sex-craving married woman of a shoe salesman. Her career focused about completely around this series for its 10 season begin (by having a exception of many television pic.)

When a prevent of Married...great, many extrthe television film followed for Sagal, & she was besides a featured voice on the babies's cartoon Recess. Around 1999, Matt Groening, who created The Simpsons, cast her as a single-eyed alien spaceship pilot Leela in his sci-fi cartoon comedy Futurama. the indicate developed a cult charted however was cancelled quaternity years late. There is no faster got that door closed than she wwhen cast as a married woman of John Ritter in the sitcom 8 Simple Rules for Dating My Teenage Daughter in 2002. Fallowing John Ritter's unexpected demise around September of 2003, Sagal was suddenly given the hard project of getting to carry virtually all of the weight of the indicate (by having a bit assist from either recently cast members David Spade and James Garner). Ritter completed lone triad episodes of the 2nd year of Octad Elementary System for Dating The Teenage Daughter by having Sagal introducing both episode. A indicate was cancelled around 2005 after its third season.

Sagal is likewise an accomplished songster. Inside 1976, spell the member of The Class action By having There are no Title, she contributed to the album "Moon Over Brooklyn". She too perfomed backing vocals on the solo album by KISS Bassist Gene Simmons. In April 19, 1994, she released her foremost solo album known as Well.... Ten years late, in June 1, 2004, she released her 2nd album Room.

Inside 2005, she had the guest apperance in Lost appearing as Helen on the episode Orientation.

Sagal married Kurt Setter in October 2, 2004. Prior to that, she was married to Freddie Beckmeyer (1978 - 1981) and Jack White (November 26, 1993 - July 24, 2000) with whom she got deuce tykes.